Low concentrations of Lactobacillus rhamnosus GG ( Yoba®) are safe in male Drosophila melanogaster

Article Authors: Keneth Iceland Kasozi, Aisha Bukenya, Ejike Daniel Eze, Josephine Kasolo, Dickson Stuart Tayebwa, Fred Ssempijja, Joy Suubo, Andrew Tamale, Isaac Echoru, Ibrahim Ntulume, Sarah Kemuma Onkoba, Lisa Nkatha Micheni, Emmanuel Tiyo Ayikobua, Oscar Hilary Asiimwe and Muhamudu Kalange

Abstract

Objective: The purpose of the study was to generate information on the safety of probiotics, thus the study objectives were to evaluate the effects of Yoba® on basic physiochemical properties. The study assessed male w1118 Drosophila melanogaster which were provided food supplemented with Yoba® at 1%, 3%, 6%, and 12% on motor function, total protein, catalase activity, and hydrogen peroxide scavenging activity and lifespan.

Results : Yoba® at high concentration (??6%) increased locomotor activity in Drosophila melanogaster, however, total protein, catalase, and hydrogen peroxide scavenging activity were significantly higher at 1% Yoba® compared to 3%, 6%, and 12% Yoba®. Yoba consumed at 1% was associated with greater physiological benefits in Drosophila melanogaster. Findings in the study offer a rationale for the consumption of Yoba® at 1% in humans as is currently being promoted by the Yoba for Life consortium, however, high concentrations of Yoba® would disrupt physiological function as shown by this study.

 

 

 

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University Researchers

  • Affiliation

    Department of Physiology, College of Health Sciences, Makerere University, Box 7062, Kampala, Uganda.

    College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, Box 7062, Kampala, Uganda.