Cytotoxicity of isoflavones from Millettia dura

Abstract

The first phytochemical investigation of the flowers of Millettia
dura resulted in the isolation of seven isoflavones, a flavonol and
a chalcone. Eleven isoflavones and a flavonol isolated from various
plant parts from this plant were tested for cytotoxicity against
a panel of cell lines, and six of these showed good activity with
IC50 values of 6-14 lM. Durmillone was the most active with IC50
values of 6.6 lM against A549 adenocarcinomic human alveolar
basal epithelial cancer cell line with low cytotoxicity against the
non-cancerous cell lines BEAS-2B (IC50 ¼ 58.4 lM), LO2 hepatocytes
(IC50 78.7 lM) and CCD19Lu fibroblasts (IC50 >100 lM).